Update: House spending panel restores U.S. ban on gene-edited babies

first_img Update: House spending panel restores U.S. ban on gene-edited babies Claude Cortier/Science Source By Jocelyn KaiserJun. 4, 2019 , 1:45 PM Lawmakers have dropped language in a draft spending bill that bars embryo editing to create a baby.center_img *Update, 4 June, 1:25 p.m.: By voice vote, the full Appropriations Committee of the U.S. House of Representatives today restored language to a 2020 spending bill that bars the U.S. Food and Drug Administration (FDA) from considering requests to approve any clinical trial “in which a human embryo is intentionally created or modified to include a heritable genetic modification.” Late last month, an appropriations subcommittee had removed the rider, which has been part of the spending bill that funds FDA for the past 4 years. Today, Democrats who lead the spending panel said they had removed the rider because they wanted to spur a fuller debate on how the U.S. government should regulate the genetic modification of human sperm, eggs, or embryos. In particular, they said that although they support a ban on using gene-editing tools such as CRISPR to modify babies, they were concerned that the FDA rider might also hinder the development of potentially helpful therapies, such as modifying a cell’s mitochondria to prevent heritable diseases. Several Democrats said they were reluctantly supporting the request from Republicans to restore the rider, and lawmakers from both parties suggested congressional health committees that shape agency policies need to address the issue comprehensively, rather than have it debated annually during the appropriations process.Here is our previous story from 24 May:A Democrat-led spending panel in the U.S. House of Representatives has dropped a provision that banned embryo editing with the intention of creating a baby. The draft bill is still moving through the legislative process, however, and Republicans will likely push to restore the language.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) The ban was first added to the law that funded the U.S. government in 2016. It bars the Food and Drug Administration (FDA) from considering any clinical trial application “in which a human embryo is intentionally created or modified to include a heritable genetic modification.” Although a different “rider” bars the National Institutes of Health from funding human germline editing—or the genetic modification of sperm, eggs, or embryos—such work is permissible with private funding. However, researchers would need FDA approval for a clinical trial.A 2020 draft spending bill approved on 23 May by the House appropriations subcommittee that funds FDA does not contain the rider, as CQ first reported yesterday. A Democratic aide speaking on background told ScienceInsider: “The provision was dropped because it was inserted in private 3 years ago and has never been subject to public debate. We believe this provision could limit important scientific research and, if Congress chooses to prohibit such research, that should be done in the light of day.”The rider has served as a de facto U.S. ban on germline editing to create a baby, which is explicitly barred in some countries. Concerns about such experiments intensified in November 2018, when a Chinese scientist announced he had used the CRISPR gene-editing tool to modify the genome of twin baby girls in an effort to make them resistant to HIV. That work, which did not go through proper regulatory approvals in China and has been widely condemned as unethical, has drawn calls from some scientists and bioethicists for a global moratorium on human embryo editing.But some scientific advocacy groups dislike the FDA bill language because it means Congress made the decision, not scientific and regulatory experts. Sean Tipton, chief advocacy, policy, and development officer at the American Society for Reproductive Medicine who is based in Washington, D.C., says the provision was “an antiscience rider.” Removing it “allows the FDA to do its job.”Bioethicist Hank Greely of Stanford University in Palo Alto, California, agrees the language was “bad policy.” He adds, “This is a good change, but it raises new challenges, for Congress and for society.”Dropping the provision frees FDA to consider allowing a less controversial approach that combines genetic material from a mother, a father, and an egg donor to prevent an embryo from inheriting a mother’s mitochondrial disease, Greely notes. That “three-parent embryo” treatment is being tested in clinical trials in the United Kingdom and has been endorsed by U.S. experts. “It is much farther along … and U.S. clinical trials should not be under a blanket ban,” Greely says.The top Republican on the House appropriations agriculture subcommittee, Representative Jeff Fortenberry (R–NE), opposed removing the embryo editing ban. “Starting in 2016, the subcommittee acted to prevent an emerging science that would allow for the permanent modification of an individual’s genetics and those of future offspring. This is a prohibition that is accepted by nearly every nation in the world due to the unknown risks,” Fortenberry said.The rider could still be added to the bill when it is taken up by the full House Appropriations Committee or when it reaches the House floor. The Senate has not yet crafted its version of the spending bill.Correction, 4 June 2019, 2:52 p.m.: As the result of an editor’s error, an update to this story incorrectly reported that the 4 June voice vote to restore the rider was unanimous. One Democrat, Representative Debbie Wasserman Schultz (FL), voted against restoring the rider.last_img read more

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Embattled Russian scientist sharpens plans to create gene-edited babies

first_img Rebrikov counters that potential parents, properly informed of the risks, should make the decision. “How do they estimate the quality of life of their babies?” he asks “Yes, hearing is not a life-or-death issue, but parents can say, ‘Well, we think that we very strongly want our child to have hearing.’”Pavel Tishchenko, a bioethicist at the RAS Institute of Philosophy who organized this month’s meeting there with Rebrikov, strongly challenged this idea at the gathering. “Just agreement of some patients is not enough for many reasons,” he said. “What will you tell the patients? The whole truth or just a part of it?” Will they know, Tishchenko asked Rebrikov, that germline editing was declared premature by an expert committee from the World Health Organization (WHO) and, separately, a prominent group of scientists who wrote an editorial in Nature? (Rebrikov says he will make his informed consent documents public.)Tishchenko questioned whether Russian society is ready for germline editing, and he worried that Rebrikov’s proposal will not get close scrutiny from regulators. The Ministry of Health has a competent ethical committee, he told the gathering, but he has less faith in other levels of review within Russia. “We have a lot of ethical committees who will say yes to any innovations,” he said.The ultimate question, Tishchenko said, is who is accountable if the child suffers a bad outcome? Rebrikov said that if regulators OK an experiment and something goes wrong, the researcher should be absolved. But Tishchenko recalled the story of a man at a sporting event in ancient Greece who threw a lance that killed a spectator. “Who is responsible? The one who threw the lance or the organizer of the lance-throwing competition?” he asked. “The question is not answered until this day.” Egor Prokhortchouk, Russian Academy of Sciences Research Center of Biotechnology Sergey Ponomarev The clinical use for gene editing is like taking something out of the air, it’s imagined. Related content Embattled Russian scientist sharpens plans to create gene-edited babies Yet unlike He, Rebrikov has been open about his intentions. He plans to seek rigorous ethical and regulatory review. He would use the technology to treat inherited deafness, addressing a medical need that is arguably more compelling than the theoretical one He chose. Rebrikov says he has a detailed research plan to assess the risks of altering embryos with CRISPR before he makes any attempt to implant them. And whereas He had no expertise in reproductive medicine, Rebrikov works as the chief geneticist at the country’s largest government-run in vitro fertilization (IVF) clinic.Rebrikov’s critics have made a bevy of assertions about his motivations, suggesting he wants fame and glory, grants for his institution, wider acknowledgement that Russian scientists do cutting-edge research, or to prod the country’s strict regulators to loosen up control on many fronts. A stocky 43-year-old who is a former champion in sambo, a Russian martial art that combines judo and wrestling, Rebrikov deftly ducks those charges and counter punches; he calls them speculations and dismisses the claims with a “ha ha” or a shrug. Rebrikov stresses his belief that germline editing has great promise to help people. “When I see a new technology come forward, I want to see how it works and how I can improve it. I am doing research at the speed that natural biological factors allow.”Some highly respected scientists in Russia who know Rebrikov well openly support his efforts. Sergey Lukyanov, a molecular biologist who heads the Pirogov medical school—and is Rebrikov’s former Ph.D. adviser and frequent collaborator—agrees that germline editing is premature for now. But he supports Rebrikov’s step-by-step approach. “[Rebrikov] is one of these people who takes action towards any imperfection of the universe that can, from his point of view, be corrected. For him, this is an opportunity to give happiness to parents to have healthy children.”Rebrikov takes the sharp criticism in stride. “People are usually very conservative, and that’s normal,” he says. Rebrikov, in contrast, says he has a high tolerance for risk if there’s a substantial benefit at stake. “In sports school, we were taught to win without thinking about the magnitude of the problem,” he says.Some opposition he suspects comes from the many scientists who are religious. “For me, it’s strange that some people believe in God and make experiments with DNA,” he says, asserting that these people have “cockroaches in their brains”—a Russian phrase meaning they are confused, if not delusional.Critics, even after learning the details of Rebrikov’s plans at the meeting, think he is the one with cockroaches in his brain. “The clinical use for gene editing is like taking something out of the air, it’s imagined,” Sergey Kutsev, a clinician who heads Moscow’s Research Centre for Medical Genetics and is the top genetic adviser to the Ministry of Health, told the gathering. Aside from reservations about whether the deafness mutation Rebrikov has targeted is a good choice, Kutsev insisted that the chance of causing harm with CRISPR germline editing is too great for any genetic condition. “I’m absolutely sure the technology’s not ready, the same as every other doctor.”Rebrikov acknowledges the scientific consensus that a bright red line now prohibits germline editing because the young CRISPR technology remains too error prone. Yet to the utter dismay of many colleagues, he has put his toes right on the line. And he is forcing Russia and the world at large to confront the key question: How, exactly, do you responsibly cross it?Cowboy or careful?Rebrikov first discussed editing embryos at a conference in Kazan, Russia, on “postgenome” technologies in October 2018, nearly 1 month before the He story would explode. “I was really surprised that in the full auditorium of 500 people he was freely speaking about this issue,” says Egor Prokhortchouk, a genomics specialist at RAS’s Research Center of Biotechnology in Moscow. Even though Rebrikov’s study didn’t violate Russian regulations, Prokhortchouk still thought it was pushing the limits of what the strict science and health ministries would allow. Critics of Denis Rebrikov doubt he has the bioinformatics power to effectively detect the many off-target mutations that may occur when CRISPR edits an embryo. RAS has not spoken publicly about human germline editing, even though many science academies around the world have called human germline editing premature. One reason may be that many Russian scientists did not take Rebrikov’s pronouncements seriously. “When I first heard about this proposal, I considered this a bad joke because our country overregulates research,” says Raul Gainetdinov, a psychiatrist who heads the Institute of Translational Biomedicine at St. Petersburg State University. “We stumble like hell. We cannot push anything through the Ministry of Health.” Gainetdinov adds that only a handful of labs in Russia even do germline editing in animal models.Elena Grebenshchikova, a bioethicist at RAS’s Institute of Scientific Information on Social Sciences, told the Moscow meeting attendees that she is glad Rebrikov pushed these issues into the public arena in Russia. “There’s a lack of communication between scientists and the society,” she said. “His openness to the subject is really a plus to shift the responsibility from a simple scientist or an institution to the shared responsibility where all of society is included.”Rebrikov has grown weary of the frenzied media, some of which has badly misrepresented his work and plans. He will no longer offer a timeline when asked when he might be ready to seek approval to implant an edited embryo. “That’s a very strange question because now, we’re not making babies, we’re just proceeding in a scientific way.” Working with nonviable embryos made at his IVF clinic—part of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology—Rebrikov and his co-workers used CRISPR to introduce a deletion into a gene for a protein, CCR5, that studs the surface of white blood cells. People who naturally inherit a defective CCR5 gene from both parents are highly resistant to HIV and suffer no dramatic ill effects from the protein’s absence; this is the same gene that He tried to cripple in the twin girls. But Rebrikov’s experiment—which joined about a dozen such human embryo-editing studies published to date, mainly from Chinese researchers—simply explored the efficiency of CRISPR. He did not discuss implanting edited embryos. “Everybody was interested in technical details and nobody asked questions about ethical things,” Prokhortchouk says.In February, however, Rebrikov disclosed his greater ambitions to Prokhortchouk and his medical students. Rebrikov and his colleagues had described the CCR5 embryo study in the Bulletin of RSMU, which led Prokhortchouk to invite him to a student journal club to discuss the paper and He’s experiment. “Rebrikov insisted that he wants to create CCR5-edited babies and that this will protect them from HIV infection from their mothers,” says Prokhortchouk, who was—and remains—opposed to such plans.Rebrikov says from the outset he was not interested in preventing a specific medical ailment, but rather to prove that he could safely help people with germline editing, which he believes will one day be widely used. He wanted to build his case by finding people with rare medical situations that would warrant the risk. He hoped to identify, for example, women who were living with HIV and wanted babies but were not responding to marketed antiretrovirals, which powerfully reduce the risk of mother-to-child transmission. Using IVF to create embryos homozygous for the CCR5 mutant in theory could help prevent infection from their mothers. The untold story of the ‘circle of trust’ behind the world’s first gene-edited babies Sergey Kutsev, Research Centre for Medical Genetics Deaf couple may edit embryo’s DNA to correct hearing mutation It was strange to me that Russian scientific society was not reacting at all. If the number of new mutations is in the range seen normally in unedited embryos—about 100 per embryo—he will move to the next stage with the remaining edited embryos: a preimplantation test, commonly done in IVF, in which five to seven cells are removed from an early embryo and their genomes analyzed. In this case, he will check the cells for many types of genetic defects and for mosaicism for the CRISPR edit. But there could be other cells in the blastocyst that have unaltered GJB2 genes or off-target changes. “We always will have some limits of the technology,” Rebrikov says.With help from a Moscow hearing clinic, this summer Rebrikov identified five couples who are likely homozygous for 35delG and certain to have a deaf child. He has met one—though the husband and wife have yet to decide whether they want to participate in his experiment.Several clinicians and researchers who specialize in hearing loss say they do not believe such couples should take the risk of editing their embryos. For one thing, 35delG homozygotes sometimes only have mild hearing impairment. They also note that a proven alternative is available: a cochlear implant, an electronic device that stimulates auditory nerves. It can restore some hearing and is particularly successful when young children undergo the surgery. People homozygous for 35delG mutations “do really well with cochlear implants,” says Richard Smith, an otolaryngologist and researcher at the University of Iowa in Iowa City. Smith and others question Rebrikov’s decision to focus on deafness, a condition that some people with hearing loss do not see as a disability. Smith says he would pick something more “lethal.”David Corey, a neurobiologist at Harvard Medical School in Boston who specializes in the molecular basis of hearing loss, adds that several biotech companies are trying to develop therapies that can correct the mutation in children after they’re born. “If I were a parent, I’d wait for a gene therapy delivered only to the affected cells,” Corey says. Sergey Ponomarev This story was supported by the Pulitzer Center.Earlier this month, Denis Rebrikov went to an old mansion in Moscow that now houses the Russian Academy of Sciences’s (RAS’s) Institute of Philosophy to confront his critics and set the record straight. Rebrikov was a well-regarded but little-known geneticist across town at the Pirogov Russian National Research Medical University when a June news article in Nature revealed his controversial plan to alter the DNA in human embryos with CRISPR, the powerful genome editor, and then implant them so they could develop into babies. He has subsequently become the focus of worldwide attention—and widespread condemnation in Russia and elsewhere as a reckless self-promoter.At the opening of the meeting, attended by bioethicists, geneticists, and clinicians, Rebrikov lamented that the group wanted to debate the merits of his proposed experiment before he had a chance to describe it in detail. “People are discussing my thoughts and my intentions as if I’m not here,” Rebrikov said. “In Russia, we have a saying, ‘I have not read [Boris] Pasternak, but I have my opinions about him,’” he added, referring to the author of Doctor Zhivago. “That’s my case.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The fury that Rebrikov has faced builds on the outrage surrounding He Jiankui, the Chinese scientist who startled the world in November 2018 when news broke that he had stealthily used CRISPR to edit human embryos in an attempt to make them resistant to HIV and then implanted them, leading to the birth of twin girls. Not only had He proceeded with flimsy regulatory review, but the girls were not facing any immediate risk that could outweigh the potential harm the editing could cause. As a result, He lost his university job, got booted from a biotech he started, and is subject to ongoing government investigations. He’s experiment also sparked new calls for a moratorium on any further germline editing—making DNA changes that can be passed to future generations, which is what He did and what Rebrikov’s embryo edits would do as well. Two high-level panels were formed with representatives from several countries—but not Russia—to examine the ethics of such work and how to regulate it. By Jon CohenOct. 21, 2019 , 6:40 PM Elena Grebenschikova, Russian Academy of Sciences Institute of Scientific Information on Social Sciences Bioethicist Pavel Tishchenko says the question of whether to edit and implant embryos cannot simply be left up to parents. Sergey Ponomarev Such larger questions won’t be resolved anytime soon. But will Rebrikov’s proposed experiment even clarify the safety of germline editing? Science asked several researchers who have expertise in DNA sequencing about Rebrikov’s plan to search for off-target effects in blastocysts. To a person, they argued that his team would likely miss too many mutations caused by CRISPR.Spotting these unintended edits “is not trivial,” says Fyodor Urnov, scientific director of the Innovative Genomics Institute at the University of California, Berkeley, who has opposed editing of human embryos even for research purposes. Even with state-of-the-art sequencing machines like the one Rebrikov says he will use, it would take sophisticated bioinformatics to detect the rare mutations in the 250 cells of a blastocyst. Urnov, a native of Russia, says it would be “very impressive” if Rebrikov could develop the necessary customized computational algorithm to compare the genomes in an embryo to its parents and detect these mutants.Urnov notes that other groups that have edited human embryos with CRISPR have found troubling levels of off-target mutations. If Rebrikov developed a convincing way to identify such mutations and found that they were few, would that alter Urnov’s confidence in germline editing? “Yes it would,” he says. “From its current state of zero confidence.”Conversation starterThe day before the Institute of Philosophy meeting, the Russian Ministry of Health broke what many had seen as its curious silence about germline editing. “Issuing permission to edit the human genome in clinical practice would now be a premature and irresponsible measure,” it said in a press statement, noting that this was in line with the WHO expert committee on human genome editing. Korobko, who heads the ministry’s department of science, innovation, and biomedical health risks, says the statement came in response to yet another media account of Rebrikov’s plans, this one in Kommersant, an influential Russian newspaper.Legally, Korobko says, Rebrikov’s work could fall under existing IVF regulations that make it illegal to create embryos for research purposes, but now, “It’s not prohibited.” Rebrikov’s earlier studies were on discarded IVF embryos, and his future plans arguably would not strictly be fundamental research but a clinical trial that aims to help a couple have a healthy baby. Still, Korobko doubts an ethics committee at the ministry would approve a permit for a clinical trial of germline editing. “The recommendation of the WHO means a lot to the Russian Federation,” he said. Sergey Kutsev, director of Moscow’s Research Centre for Medical Genetics, has sharply criticized Denis Rebrikov’s suggested experiment. His openness to the subject is really a plus to shift the responsibility from a simple scientist or an institution to the shared responsibility where all of society is included. Rebrikov’s initial CRISPR embryo experiments aimed to better gauge the risks and challenges. Ideally, when CRISPR is introduced right after an egg is fertilized, it will make its desired edit at the one-cell zygote stage, so that as the embryo divides, all cells are corrected. But if CRISPR enters at the two-cell stage or later, it may create a child who has the desired change in some cells but not others. This mosaic child could still be vulnerable to HIV. But out of eight embryos edited using CRISPR, Rebrikov’s team found evidence of mosaicism in only three of them at the blastocyst stage, when they are 5 days old and have about 250 cells. Still, the study did not assess the equally concerning possibility that the editing would create accidental, “off-target” mutations; theoretically, these could trigger a cancer or cause other health problems. Rebrikov’s publication attracted little attention: A Chinese team had published similar work 2 years earlier—and Bulletin of RSMU is obscure.Only when Nature ran its news story, which said he hoped to implant an edited embryo within 6 months, did Rebrikov’s plan begin to draw more widespread scrutiny. Leading CRISPR scientists and bioethicists outside of Russia slammed Rebrikov’s plans as “irresponsible,” “unsettling,” and “a slippery slope,” charging that he was a “cowboy” who had “weak data” and was trying to “grab some attention.” Rebrikov rejects assertions that he hyped his plans and stresses that he didn’t seek any of the media attention. “If somebody called me and asked, ‘Would you answer my questions?’ OK, well, why not?” he says, noting that he has stopped replying to most media requests.But the attention led to a July meeting, instigated by Prokhortchouk and hosted by Kutsev. “It was strange to me that Russian scientific society was not reacting at all,” Prokhortchouk says. Among the 10 attendees, to Prokhortchouk’s surprise, was a pediatric endocrinologist, Maria Vorontsova. She is widely reported to be Russian President Vladimir Putin’s daughter, although no one in the family has confirmed that. (Putin has demanded that his private life remain private but has acknowledged having daughters and grandchildren.) Vorontsova’s presence prompted a Bloomberg story on 29 September with the headline: “Future of Genetically Modified Babies May Lie in Putin’s Hands.” It suggested the meeting was “secret” and, with little evidence, that Vorontsova might influence Putin’s position on germline editing and, in turn, its fate in Russia. “The meeting was not secret,” retorts geneticist Igor Korobko, a Ministry of Health official who attended. “And we have rules and laws: It’s not the president’s decision.”A detailed planRebrikov couldn’t find any HIV-infected women who didn’t respond to antiretrovirals and also wanted to get pregnant. So he recently switched gears and sought hearing-impaired couples who are homozygous for a mutation known as 35delG in a gene, GJB2, that produces a protein in gap junctions, the channels that help move chemical signals like potassium between cells, including in the inner ear. The 35delG mutation, in which a single incorrect DNA base cripples the protein the gene codes for, is one of the most common genetic causes of hearing loss. Rebrikov wants to use CRISPR to replace the aberrant DNA base with the correct one.Rebrikov told Science that he plans to do extensive safety checks before seeking approval to implant an edited embryo. First, he wants to sequence the entire genomes of each parent to get a baseline for assessing off-target mutations in their edited embryos. He then wants to stimulate the woman’s ovaries, obtain about 20 eggs, fertilize them with her partner’s sperm, and finally add the mutation-fixing CRISPR. He’ll grow these embryos for 5 days, at which point they will have about 250 cells and be in the blastocyst stage. Then he will do repeated rounds of whole-genome sequencing of 10 of these blastocysts, which aims to reveal all mutations that differ from the genomes of the parents.last_img read more

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Balotelli furious with Dessena injury

first_img Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/ Mario Balotelli has expressed his fury after the VAR did not intervene before Brescia teammate Daniele Dessena was stretchered off. Dessena was in tears as he left Brescia’s 0-0 draw with Fiorentina last night on a stretcher, risking a double break in the right leg he broke four years ago. However, the incident came about after a collision with Erick Pulgar, who looked to catch his opponent’s ankle. That promoted Balotelli to write an Instagram post, captioning a frame of Pulgar’s challenge with ‘VAR?’ The video referee chose not to consult referee Giampaolo Calvarese for a review, so the Fiorentina midfielder went unpunished. Dessena will undergo tests on Tuesday to determine the extent of the damage he has sustained.last_img read more

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Koke: ‘Bad memories from Turin’

first_imgAtletico Madrid midfielder Koke admits to having bad memories from Turin but believes Juventus are more than just Cristiano Ronaldo. Last season, a 2-0 home win against Juve was not enough to get Atleti past the Round of 16 as they were sent out of the Champions League by a Ronaldo hat-trick at Allianz Stadium. “Our last memories from Turin are not positive,” Koke said at a press conference. “Tomorrow we will do everything we can to win.” Los Colchoneros need the three points to book thier place in the knockout stages, whilst the Bianconeri are already through to the next phase. “We know we are playing one of the best and we will do what we can to get there. Every game is different, you need to step on the pitch with a desire to win. “We need to be more determined than we were last time we came here. Our advantage is that we have trained a lot and very well, we will do everything we can to win.” Even though CR7 proved decisive last time out, the Spaniard warned his team could ill-afford to forget about other potential threats. “I look at all of Juventus, who are of a high level. Cristiano Ronaldo is not the only one, but he has scored so many goals. “We will see if we can have a game like him.” The first match between the sides in Group D ended in a 2-2 draw at Wanda Metropolitano. Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/last_img read more

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Munaf Patel to replace injured Sreesanth

first_imgMunaf Patel will replace pacer S. Sreesanth after he was ruled out of the entire Test series between India and Sri Lanka. Asked to lead the pace attack in the absence of Zaheer Khan, Sreesanth encountered a knee injury and missed the team’s practice session on Sunday.  He underwent an MRI scan following which the decision to keep him out of the team was taken. Sreesanth’s absence will weaken India’s already depleted pace attack in the Test series.  To add to the problem, spinner Harbhajan Singh too missed the practice session because of fever.  Starting Tuesday, India is scheduled to play a three-day warm-up game against the Sri Lanka Board President’s XI.last_img read more

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Booked in

first_imgTathagat A. TulsiNever shy away from hard work. People with extraordinary talent are usually forced to fight for themselves, but this should not deter them. The arrow of time: Since a very young age, I have been fascinated with physics and its various theories. Initially, I used to read popular,Tathagat A. TulsiNever shy away from hard work. People with extraordinary talent are usually forced to fight for themselves, but this should not deter them.The arrow of time: Since a very young age, I have been fascinated with physics and its various theories. Initially, I used to read popular science books by Stephen Hawking and many other physicians, but later I developed a natural talent for it. My command over mathematics was also good because of my speed to grasp its concepts. This made me a much faster learner and I was far ahead of the students of my age.The PSI factor: Studies and age had nothing to do with my thirst for knowledge, I just wanted to read and research. I never attended any school, in fact I was home schooled by my books. Leisure activities like sports and games often bored me, so I never felt the need to leave my books and do something else. I was enthralled by everything I read and I wanted to know more. It was a natural progression and I was addicted to gaining knowledge.Time off: Most of my life, I have had a hunger to know more about science. But now that has lessened. I try to maintain a balance in whatever I do. My idea of a perfect holiday is spent learning new things and unwinding at home. These days I am studying biology. It is, however, not the only thing in my life. I also try to play sports, badminton in particular. Although, I do not spend much time watching movies I am fond of Bollywood films and try to catch the good ones. I recently saw 3 Idiots and liked it very much.Home sweet home: I absolutely love home cooked food with roti, sabzi and dal. In fact I am quite fond of bhindi and if the food is topped by Bengali sweets, it is surely a cherry on the cake.The perfect academician: Balance is the key to becoming a good academician. It is important to maintain equilibrium between research and teaching. These attributes will not only nurture learning abilities but also enable one to contribute to the society.A quantum leap: I have always dreamt of winning the Nobel Prize and today I can say with some confidence that I am working toward it. As of now, my research is still in the nascent stage and although it is risky business, I would like to see myself as a researcher and a contributor. But more importantly being a good human comes before everything.Pearls of wisdom: Not many students are interested in studies but with dedication and hard work nothing is unachievable. Many a time people with extraordinary talent are forced to fight for themselves, but this should not deter them. In fact, this should be a reason to keep going. Tathagat A. Tulsi, 22Born on September 9, 1987 in Patna, Tathagat Avatar Tulsi is a child prodigy. He finished his high school at the age of nine, earned a B.Sc degree at 10, an M.Sc. degree at 12 and then received his Doctorate in Quantum Computing from the Indian Institute of Science, Bangalore, at the age of 21. He has now been recruited at the Indian Institute of Technology, Bombay, as an assistant professor making him the youngest faculty at any IIT in the country.advertisementlast_img read more

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Big ideas for 2012

first_imgThe most exciting part about a New Year are the beginnings we chose for ourselves, and as the zeitgeist of 2011 has proved, these plans will have to made with caution and creativity. In the first month of the year, six women share with us their big ideas for 2012.,The most exciting part about a New Year are the beginnings we chose for ourselves, and as the zeitgeist of 2011 has proved, these plans will have to made with caution and creativity. In the first month of the year, six women share with us their big ideas for 2012.Kalki Koechlin, 28, Actor, Mumbai”My plan is to escape Mumbai for a few months to pursue my passion for theatre and writing.”Lifeline: The current queen of alternative cinema, she first found her calling on the stage while studying theatre in London. She moved quickly from ads to playing the modern Chandramukhi in Anurag Kashyap’s DevD, with the sass and confidence seldom seen in outsiders to the industry. 2011 was a mixed bag for Koechlin- she transitioned into the mainstream with Zoya Akhtar’s Zindagi Na Milegi Dobara, and proved her acting mettle in That Girl In Yellow Boots, which she co-wrote with husband Anurag.The gameplan: The last year has been a whirlwind professionally. With two releases, between shooting schedules and promotions, I’ve hardly had any time. When I’m back in Mumbai around mid-February, I will begin shooting for my new film, Shanghai, a fast-paced political thriller. I’ve consciously taken these few months off to focus on my writing and theatre, since I enjoy both immensely. I will be in a Tom Stoppard play soon and focus on writing new scripts. This year is going to be about letting my creativity flow.Kalyani Shastry, 34, Lead Consultant, StantonChase, Mumbai”It’s the year of change, of questions and reform. I welcome it.”Lifeline: Involved in strategic hires for multinationals, Kalyani Shastry gets the bosses their top jobs. She’s helped place people at leadership levels in companies like SREI, TVS Capital, Microsoft, Ernst & Young to name a few, and is an ace at identifying great talent.The gameplan: I’m looking forward to some economic sunshine for India in the New Year. While I don’t believe in resolutions, I do look forward to new beginnings. My goal is to strike a healthy balance between work and home. Since the workplace is always evolving, my approach will be aggressive and I want to find newer avenues for growth. On my personal bucket list is some more metime, pursuing wildlife photography and trying new adventure sports with the family.advertisementAditi Mittal, 24, Comedian, Mumbai”2012 is going to be the year of the artist and cinematic genius.”Lifeline: A lone ranger in a world where all the laughs belong to men, Aditi Mittal has brought her own feminine sensibilities to Indian standup. With material on good sex to Pakistan, Mittal has found recognition from a middle-class now confident enough to laugh at itself.The gameplan: To keep a New Year resolution, make it in reverse. If you break it, you end up winning. Learning new things is my mantra for 2012. I feel like I’ve only nudged the top of a massive iceberg. The Indian audience in the metros is growing up and accepting diverse forms of humour. I think 2012 should be the year where more comedians like me should jump into the fray. I’ve also resolved to be a better daughter and friend, and keep in touch with people who count. To top off that bucket list is a trip to Romania and waiting patiently for more versions of Kolaveri Di to hit the viral waves.Hastha Krishnan, 53, CEO, Global Search Services, Ma Foi Randstad, Chennai”I’m going to be a mentor to my juniors and facilitate solutions in an inclusive manner.”Lifeline: This English Literature graduate-turned-market research professional is Ma Foi’s pillar of strength in India. Having expanded her portfolio to include CEO level posts, Krishnan is now responsible for matching talent to industry requirements right from entry-level positions to top-level management.The gameplan: Being part of a management development programme in 2011 made me introspect on my own leadership style. My approach so far has been unilateral and directive, while there is now a need for more mentors in the industry. I will try a more inclusive style, and be an encouraging soundingboard for new ideas. I will balance out the co-existing spheres of my life, which means spending more time travelling with family. Giving back through the Ma Foi Foundation for child healthcare, education and women’s empowerment is going to be a major goal for me in 2012.Kavitha Iyer Rodrigues, 34 Co-founder, Inbiopro, Bangalore”It’s time for some rules in bioscience and I plan to enforce them.”Lifeline: A Tamilian from Bangalore, Kavitha Iyer Rodrigues co-founded Inbipro, a bio-pharma start-up, in her parents’ apartment in 2007. Since then, the business has grown exponentially and is being touted as the next big thing to hit Indian pharmaceuticals.The gameplan: Inbiopro will be launching its first product in 2012. But till that happens, my plan is to introduce process control and quality management systems in bio-pharma-set a benchmark for the industry as a whole. I’m passionate about running marathons and I’m going to run more in 2012. With being a Tai chi practitioner and a mother of a three-year-old, I’ll have my hands full through the year.advertisementSrividhya Ramarathnam, 38, Business Head, New Technology Initiatives, Intuit India, Bangalore”The buzzword for 2012 will continue to be the youth. Their enthusiasm is infectious and driven.”Lifeline: A successful consultant in the US, Ramarathnam returned to a surging Indian market, which, according to her, has more “innovation and excitement” than the west. She’s in charge of Intuit’s newest Indian venture, txtWeb India. Aimed at the 700 million mobile phone users in the country, txtWeb is a service that can connect you to the information you want by means of a single text message, without needing the internet. It’s democratisation of knowledge, claims Ramarathnam, and the newest means to empowerment.The gameplan: The immediate goal for txtWeb would be to penetrate the market further, especially amongst the youth who use text messaging the most. Through a host of NGO players, we hope to break into the rural market soon, where this application will prove most useful. Personally, I adopted a new role, and a new challenge when I joined Intuit India in 2011. From marketing and selling well-established products in the US, to taking on a brand new initiative in India, the last year’s been a huge change for me. My role has evolved into looking after enterprises started from scratch and turning them into profitable ventures. To get away from my busy schedule and since travel is a good way to unwind, I definitely want to take more trips with my husband and explore the North-east with him. With India growing as an economic powerhouse, what I’m most excited about is how people are taking to projects like microfinance, which permeate down to the weaker sections of society.last_img read more

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Seema Antil joins the Olympic brigade

first_imgA year ago, Seema Antil was contemplating quitting the sport but the Haryana discus thrower is now amongst the elite who have made it to the London Olympics .Seema became the ninth Indian track and field athlete to qualify for the London Games with an ‘A’ standard mark achieved at the University of California (Irvine) Open Championships in the United States on Saturday.With an effort of 62.60m, Seema also became the second women discus thrower from India after Krishna Poonia to seal a spot for the London Games.The Sonepat thrower insists that she could have crossed the 64m mark on Saturday itself if she had gone on to make more attempts. However, her coach Tony Ciarelli, with whom Seema has been training for the last six months in the US, was content with her performance in her very first effort and did not allow her to make more throws.”It was my first throw and I gave my 80 per cent effort because nobody goes all out in the very first attempt. It was good enough to get me a spot in the Olympics, so my coach insisted that I shouldn’t put too much pressure on myself,” Seema told MAIL TODAY from California on Sunday.Seema claims that she wasn’t getting the best of facilities in India and didn’t have the money to fund her training abroad. That put her almost on the verge of quitting before Mittal Champions Trust took her under their wing.”I would have quit the sport but stayed on only because Mittal Champions Trust came at the right time. They were the ones who funded my training abroad and have provided me with a very good coach.”Her goal is now to make further improvements and she believes that she will be able to reach the 65m mark by the time the Olympics begin in July.For Seema, it has been a long wait since she managed to cross the 62m mark the last time. Her personal best is 64.84m which came in 2004 after which she has never managed to go beyond 60.56m, which fetched her a silver medal at the 2006 Melbourne Commonwealth Games.Besides Seema and Krishna, Vikas Gowda is another discus thrower who will compete at the Olympics in the men’s section.For the past few years, nothing much was heard about Seema until the Delhi Commonwealth Games where she secured a third-place finish behind Krishna Poonia and Harwant Kaur with an effort of 58.46m.advertisementlast_img read more

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Ph 5 cruises past Thais

first_imgHotel says PH coach apologized for ‘kikiam for breakfast’ claim Import Isaiah Austin produced 27 points, 19 rebounds and 4 blocks for the Filipinos, who pace Group A with a 2-1 record.Lead playmaker Kiefer Ravena and Jeron Teng also impressed with 24 and 17 points, respectively. —FIBA.COMFEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games opening Winter storm threatens to scramble Thanksgiving travel plans Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Trump to designate Mexican drug cartels as terrorist groups MOST READ LATEST STORIES Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Argentine bishop appears at court hearing on abuse charges Sports Related Videospowered by AdSparcRead Next No more menthol cigarettes: New ban on tobacco, vape flavors ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Lacson: SEA Games fund put in foundation like ‘Napoles case’ Photo from Fiba.comChooks-To-Go Pilipinas leaned on a strong fourth quarter to repulse a pesky Mono Vampire squad, 115-102, at the Fiba Asia Champions Cup on Sunday at Chenzhou Sports Center in China.The Filipinos engaged the Thais in a shootout for the first three periods before pulling away in the final frame.Four Filipinos scored 17 points or more, led by Carl Bryan Cruz, who bounced back from an anemic performance the day before to lead his squad with 28 points, including eight three-pointers.ADVERTISEMENT OOM winner has eyes on another prize View comments Don’t miss out on the latest news and information. last_img read more

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Wozniacki senses ‘great’ Aussie Open despite Auckland loss

first_imgBeautyMNL open its first mall pop-up packed with freebies, discounts, and other exclusives ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims LATEST STORIES PH military to look into China’s possible security threat to power grid “Everyone wants to be number one, but it’s something I’ve done before and obviously it would be nice to do it again, but honestly I think i’m just thinking about being in the finals, holding trophies, lifting trophies.” Wozniacki started last year ranked number 19 and by the end of the year, after winning the WTA Finals, she had risen to number three.Meanwhile, Goerges is expected to rise from 14 to 12 when the next rankings come out as she enjoys a rich vein of form having won three consecutive tournaments. She is on a 14-match winning streak with her success in Auckland following victories in Moscow and Zhuhai WTA tournaments late last year.The 29-year-old German troubled Wozniacki with a big forehand that produced service breaks at the start of each set and a booming serve that delivered 11 aces. ADVERTISEMENT The current record for the longest gap between being ranked number one is held by Serena Williams who spent five years and 29 days off the top spot between August 10, 2003, and September 8, 2008. Although beaten 6-4, 7-6 (7/4) by world number 14 Julia Goerges in the Auckland final, Wozniacki said her preparation for Melbourne was on track. FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingSPORTSPrivate companies step in to help SEA Games hosting“I’ve got a lot of matches under my belt this week, it was the preparation I hoped for,” she said. “Now I can take a day off tomorrow and fly to Melbourne and get used to courts over there, and the conditions, and hopefully it’s going to be a great couple of weeks.  Caroline Wozniacki of Denmark hits a return against Sachia Vickery of the US during their women’s singles semi-final match at the WTA Auckland Classic tennis tournament in Auckland on January 6, 2018. / AFP PHOTO / MICHAEL BRADLEYCaroline Wozniacki declared she was preparing for a “great” Australian Open as she closed in on regaining the world top ranking despite a surprise defeat in the WTA Auckland Classic final on Sunday.The 27-year-old Dane is projected to rise to number two in the world when the new rankings are released on Monday and if results go her way in Australia she could make a record-setting return to number one, a position she last held six years ago. ADVERTISEMENT SEA Games: PH still winless in netball after loss to Thais Don’t miss out on the latest news and information. MOST READcenter_img Bucks rally past Wizards ‘We cannot afford to fail’ as SEA Games host – Duterte Goerges dropped her serve once, at 4-3 in the second set, but never felt her form was dropping. “It means you have to be there right away in the next game. I didn’t break her but I showed her I was still there and I was very happy that I could serve well at the end,” she said. Head-to-head, Goerges now leads Wozniacki 6-4.Sports Related Videospowered by AdSparcRead Next Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Jordan delivers on promise: 2 Cobra choppers now in PH Hotel says PH coach apologized for ‘kikiam for breakfast’ claim View commentslast_img read more

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ISL: Zico laments lack of potent striker for struggling FC Goa

first_imgFC Goa succumbed to an embarrassing 0-2 loss against FC Pune City on SundayFC Goa’s marquee manager Zico today admitted that his team lacks a potent striker, which is the reason for their three defeats in four games in the Indian Super League.Goa lost 0-2 to FC Pune City in their away game on Sunday.”The team is missing someone who can score a goal. Football is all scoring goals and we don’t have a guy who can score. Today, we had four chances to score, but there was no one to score,” the Brazilian legend lamented at the post-match press conference.Asked about if Robert Pires’s absence due to suspension made the difference, Zico said,”We shouldn’t be worried about who is there and who is not there on field. With him (Pires) on the field, we lost two matches and drew one, so I don’t how to answer that question of yours.”What was the difference between his team and Pune, pat came the reply, “Well, when we were playing well, we didn’t score and they scored.”Was it a case of defensive lapse, he said, “It wasn’t a defensive lapse. It was mistake that happens in football. At moments where we couldn’t do anything they scored. It is normal thing to happen in football. So we need someone to score a goal.”Zico was impressed with the performance of Afghanistan’s national team captain Haroon Amiri.”This is the first time I saw him playing. He is a player that made me happy with his game. He played very well. He wants to win to game. So it might be possible that he might be played in future matches. I like players like him in my team.”advertisementPune goalie Bellardi hada great time under the bar and Zico was as impressed as the others.”I know him very well because played for four years in a team that I used to play.”Quizzed how much of a loss will it be Gabriel Fernandes’ injury, the manager said,”The doctor hasn’t said anything yet. We don’t know what the status is. I hope it is not very serious because he left the field in lot of pain.last_img read more

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Captain Clarke dedicates World Cup win to late Phillip Hughes

first_imgPhillip HughesAustralia captain Michael Clarke on Sunday dedicated their cricket World Cup win to deceased batsman Phillip Hughes, who died on November 27 after being struck on the head by a bouncer two days earlier during a domestic match.Australia crushed New Zealand in the final at the Melbourne Cricket Ground (MCG). Chasing a paltry target of 184, Australia got over the line with seven wickets and 101 balls to spare.Speaking at the post-match presentation ceremony, Clarke said he would keep on wearing the blackband on his arm with PH (Phillip Hughes) inscribed on it and would dedicate the World Cup to the left-handed batsman. Hughes represented Australia in 26 Test matches and 25 One-Day Internationals.”The blackband is, you can see PH written on it. I will wear it every game I play for Australia. Tonight is dedicated to our little brother Phil Hughes. Hughesy used to party as good as any of them as we have won for him tonight,” Clarke, who scored a superb 74, said.The skipper for whom it was his last game in the yellow jersey also credited New Zealand for being a “tough team to beat” throughout the tournament.”Brendon (McCullum) and New Zealand deserve a lot of credit. (They are) always a tough team to beat, whenever we play them in any sport. So, well done to Baz and his team, especially personally, he had an amazing performance,” he said.Asked what he felt like after winning the trophy, the 33-year-old said he felt over the moon and believes they are the deserving champions.advertisement”I feel over the moon, what a tournament it has been, thanks to every Australian and cricket supporter out there who’ve been behind us. The team and support staff, the support I’ve had since coming back into the team, they deserve to stand there with the trophy,” he said.On handing his number 23 shirt to his peers, Clarke jokingly said: “Might give it back to Warney (Shane Warne from whom he got it)… Haven’t given it much though, time is right to walk away from one-day cricket but I’ll still be playing in Tests.””It’s a wonderful achievement, to win in our own backyard in front of family and friends,” he said.last_img read more

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Jamia Millia Islamia to start admissions today, four new courses launched this year

first_imgStarting today the admissions for Jamia Millia Islamia are open. The university has made certain changes regarding the admission policy, marking system and courses offered this session.JMI has taken the admission process completely online this year, there is no option of  applying offline. From the registration of candidates to issuing of admit cards, everything will be done through online mode.The Academic Council of JMI has also introduced the choice-based credit system from this academic year. The CBCS gives the students a choice to select from the prescribed courses, i.e., from core, elective, minor or soft skill courses. It enables students to opt for courses they like, learn at their own pace, take up additional courses for extra credits and adopt an interactive approach to learning.Under this system Jamia is also starting an optional exam of Northeast Studies at the undergraduate level. Opting for this paper will allow students to earn credits by studying one semester at a different university. Adoption of the grading system will help in exchange programmes for students across institutions in the country.Also, the university is starting four new courses from the session of 2015-16. These are- MA in Gender Studies by the Sarojini Naidu Centre for Women’s Studies, MSc in Biophysics by Centre for Interdisciplinary Research in Basic Sciences, PG Diploma in Public Health by Department of Social Work and Diploma in Disaster Management by Department of Geography.Apart from these programmes, there are additions to existing courses as well. In addition to the existing options ‘sports’ and ‘orthopaedics’, new specialities have been introduced in the Master’s in Physiotherapy (MPT) course, such as ‘cardiopulmonary’ and ‘neurology’.advertisementThe admissions are open for all undergraduate, postgraduate and diploma courses offered by Jamia. The interested and eligible students may apply online at the official website www.jmi.ac.in. Last date for submitting applications is May 1.last_img read more

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Akshay Kumar is Roadies winner Prince Narula’s role model

first_imgChandigarh-based Prince Narula is in a “crazy phase” of mind since Saturday night. He has won MTV Roadies X2, 12th and latest edition of the popular reality show that aims at titillating a young audience with elements of travel, adventure, drama and a hint of voyeurism. “I was always a fan of the show and participating has been a lifetime’s experience. I set out to win, and I won,” Prince told Mail Today on winning the show.In the final Prince beat Gurmeet of boxer Vijender Singh’s gang. His prize is a high-end sports bike plus a contract to work on MTV as a VJ. The 25-year-old, who introduces himself as a bodybuilder who wants to be a Bollywood action hero like Akshay Kumar, admits tasting true fame ever since he became a frontrunner. “Now when I go to a mall, people recognise me. It feels good to be famous. MTV Roadies makes you popular among the youth,” said Prince, whose family is in the fabric business. “My family supported me all throughout the show. My parents told me, ‘do what you want, just don’t get hurt’.” Prince loves spending time with friends, travelling and observing people, and he honed his competitive skills participating in Mr Punjab contest. “That was the time I realised I could be on Roadies,” he said.For Prince, there is no other reality show better on Indian TV to become instantly famous. “All youngsters are crazy about Roadies. If you want to make a mark in the world of reality TV, my advice is this is the best show,” he avers.advertisementBeyond the fun, frolic, ugly fights and drama, Roadies was a learning process. “I learnt a lot from the down-to-earth mentors. Observing them I realised you benefit in life by being yourself,” he said.last_img read more

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Record heat at Wimbledon causes issues for ball boy, players

first_imgThe heat at Wimbledon on Wednesday caused a ball boy to collapse, a player to feel “dizzy” and thermometers to rise to record levels for the tournament.In the bright sunshine in southwest London, temperatures reached 35.7 degrees Celsius (96.26 degrees Fahrenheit), according the Met Office – the highest recorded during the two-week tournament that is better known for persistent rain. While players mostly coped well with the conditions, a ball boy collapsed during a match on one of the outside courts and needed medical treatment before being taken away on a stretcher. Organizers said he recovered quickly and was doing well.”It was a very scary situation,” said John Isner, who was playing Matthew Ebden on Court 17 when the incident happened.”I have heard that he’s doing much better, which is great,” the American said after winning in straight sets. “He just needs to rest up.”So does Bernard Tomic, who needed treatment on court during his victory over Pierre-Hugues Herbert of France after getting dizzy in the heat. The Australian said he’s had trouble sleeping all week because of the hot weather.”I was fatigued and starting to get dizzy out there with the heat hitting me,” Tomic said. “It was tough, so I had to slow things down. I had to catch my breath. … It was not that easy, that situation for me in the second. I was feeling bad. Hopefully I can get a good night’s sleep in tonight.”He’ll need it before his next match against Novak Djokovic, who said he was happy to wrap up his win against Jarkko Nieminen of Finland quickly on Centre Court so he could get out of the sun.advertisement”On this warm day, it’s good to spend a little bit less time (playing) than maybe what is possible,” Djokovic said.Organizers kept the retractable roof over Centre Court closed in the morning to keep out the heat, then had it partially covering the spectators behind the baselines to give them shade. Among those sitting in the sun, hundreds of handheld fans flapped like butterfly wings in the stands.Players used towels wrapped around ice to cool down during changeovers, while on Henman Hill – where fans often brave the rain as they gather outdoors to watch the matches on a big screen – umbrellas once again dotted the green slope. This time, though, they were used as makeshift parasols to shield fans from the sun.Medical officials said dozens of fans were treated with heat-related illnesses, but no major incidents were reported. Many of the players, though, said the heat wasn’t a big deal.”It wasn’t – I don’t want to call it overrated, because it was very hot out there – but it wasn’t crazy bad,” Isner said. “There were a lot of clouds in the sky, which helped I think a lot.”Like Isner, Maria Sharapova trains in Florida and said she’s used to hotter temperatures.”It’s much warmer in my hometown of Long Boat Key, Florida,” the fourth-seeded Russian said after beating Richel Hogenkamp of the Netherlands in straight sets. “I think I’ve trained quite long in the heat over there. … You want to make the points quicker than normal because of the heat, just being a little bit smarter out there is the most important.”last_img read more

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Have learned to keep my mouth shut, says Nick Kyrgios

first_imgControversial Australian tennis player Nick Kyrgios says he has learned to keep his mouth shut at times after the controversy surrounding his recent on-court comments.A couple of weeks ago, Kyrgios had jibed at Swiss Stanislas Wawrinka during a match in Montreal saying: “(Thanasi) Kokkinakis banged your girlfriend. Sorry to tell you that, mate.”The 20-year-old was given a suspended 28-day ban and fined $25,000 by the Association of Tennis Professionals (ATP), to be imposed should he transgress again.”I’d like to think that I’m going to learn from it. I think I have. I think I’m on the right path. I don’t think any of us in this room right now were perfect at 20,” Kyrgios was quoted as saying by BBC on Tuesday.When asked to be specific about what he had learned, Kyrgios said: “Keep your mouth shut at times.” Kyrgios lost 5-7, 3-6, 6-4, 1-6 to Andy Murray at the US Open on Tuesday, his third match since playing Wawrinka.Also read: Murray beats Kyrgios to reach the US Open second roundThe World No.37 was well received by the crowd at Flushing Meadows but understood “100 percent” why some spectators had jeered him at his previous matches. “There are still people in the crowd that are unhappy with what happened. And that’s only normal,” the Aussie said.Kyrgios said he had looked up to Murray as a role model.”I’ve had a really good relationship with Andy for a long time now. Whenever I’ve needed something, I’ve come to him. I’ve sort of looked at a guy like him that’s a really good role model for everyone,” Kyrgios concluded.advertisementlast_img read more

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Vikas Krishan Yadav enters Asian Boxing Championships final

first_imgFormer World Championships bronze-medallist Vikas Krishan (75kg) was the lone Indian to make the final while three others settled for bronze medals after losing hard-fought semifinal contests in the Asian Boxing Championships here on Friday.Vikas defeated Iraq’s Waheed Abdulridha 3-0 to set up a clash with Uzbekistan’s Bektemir Melikuziev in the final on Saturday. However, Satish Kumar (+91kg), L Devendro (49kg) and defending champion Shiva Thapa (56kg) lost their respective semifinals despite valiant efforts and settled for bronze medals.All three of them had earlier assured themselves of berths in next month’s World Championships – the first qualifier for 2016 Olympics. Also making the World Championships cut were, Madan Lal (52kg) and Manoj Kumar (64kg) after the Uzbek boxers who beat them in the quarterfinals – Shakhobidin Zoirov, seeded second, and Fazliddin Gaibnazarov respectively – advanced to the final.Vikas, an Asian Games bronze-medallist, was the last Indian in action and he made sure that the contingent had something to cheer for after a largely disappointing day.Unlike his usual defensive style, the Haryana-lad was attacking in his approach and let loose a flurry of combination punches to push Abdulridha on the backfoot.The Indian, the busier of the two when it came to attack, did not allow Abdulridha to come out of the shell guard in the first round.In the second round, Vikas targetted Abdulridha’s torso, forcing him to counter-attack. Vikas then took full advantage of the defensive lapses committed by the Iraqi and connected his left uppercuts with deadly accuracy.advertisementIn the end, the 23-year-old emerged a unanimous winner, getting the nod of all three judges.”His boxing was very clean and his punches had power. In the final round, he showed how to maneuver after dominating the first two rounds. Very clinical show,” national coach Gurbax Singh Sandhu told PTI.”It is a very satisfying performance and I am glad that six of my boys made the World Championships cut,” he added.last_img read more

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SPORT-LD IND 3 LAST

first_imgKyle Abbott stemmed the rot by dismissing Kohli first and Kyle Abbott stemmed the rot by dismissing Kohli first and then Sharma in the space of four balls. The opener went for a pull but managed an edge which was taken by Morris at long leg. By that time, India were cruising with the scorecard reading 162 in 16 overs. Indian lost Raina (14) and Ambati Rayudu (0, run out) in the 19th over but skipper Mahendra Singh Dhoni (20 not out) helped India get close to 200. He finished the innings in style, hammering Abbott for a six. The quick dismissal of Sharma and Kohli did affect Indias ran rate as the hosts managed only 37 runs in the last four overs. Abbott was the only South African bowler who managed respectable figures as he gave away just 29 runs in his four overs. The dew on the ground did make it tough for the bowlers but Sharma was in sublime form as he reduced the South African attack to a pedestrian one. Rohit opened his account with an uppish cut in a tentative start as the lanky Abbott kept it outside off. He opened up after getting his eye in, pulling and driving Merchant de Lange effortlessly. Shikhar Dhawan (3), who hardly got strike, was run out when he attempted a second following a mis-field from de Lange. Sharma though grew better and better. De Lange continued to dig in short and the Indian kept pulling him. He did not spare even Chris Morris and smashed him for a six on the leg side after getting a boundary off a drive. Faf du Plessis introduced Imran Tahir as India put on board 46 after six power-play overs. The leg-spinner bowled a tight over but the pacers kept leaking runs. This time it was Kohlis turn to inflict some damage as he hammered Morris for a six and followed it up with a boundary. Sharma completed his half-century when he guided a short and bouncy one from Abbott to third man boundary. One ball later, he played a scoop for leg-side boundary as India put on board 86 after half-way stage. Tahir came in for some punishment from the two batsmen as they collected 21 runs from the 12th over. Sharma sent the first ball soaring over the ropes to bring up teams 100 and in the third ball Kohli heaved him over deep mid-wicket to complete his 1000 T20 international runs. The skipper followed it with a flat six in long-off area. PTI AT PDS PDSadvertisementlast_img read more

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