Stewardship / Resistance Scan for Aug 20, 2019

first_imgStudy supports shorter parenteral antibiotics for infants with bacteremic UTIsA study of infants who had bacteremic urinary tract infections (UTIs) indicates that short-course parenteral antibiotic therapy may be considered as a treatment option, a team of US researchers reported today in Pediatrics.In the multicenter retrospective cohort study, conducted at 11 geographically diverse US children’s hospitals, researchers with the Febrile Young Infant Research Collaborative examined the association between parenteral antibiotic duration and clinical outcomes in infants younger than 60 days who had a UTI with concomitant bacteremia. UTIs are a common bacterial infection in young infants, and approximately 8% to 10% have bacteremic UTIs. Yet no evidence-based treatment guidelines exist in this population, and infants with bacteremic UTIs frequently receive prolonged courses of parenteral antibiotics, which can lead to complications, prolonged hospitalization, and increased costs.The primary outcome of the analysis was UTI recurrence resulting in an emergency department visit or hospitalization within 30 days of discharge. Secondary outcomes included length of hospitalization and 30-day all-cause hospital reutilization.Among the 115 infants treated for bacteremic UTIs from 2011 through 2016, 58 received short-course parenteral antibiotic therapy (defined as 7 days or less) and 57 received long-course antibiotics (7 days or more). Six infants had a recurrent UTI, and no significant difference was found in the rates of recurrent UTI between the two treatment groups (adjusted risk difference, 3%; 95% confidence interval [CI], –5.8 to 12.7). Fifteen infants had 30-day all-cause reutilization, with no significant difference found in the rates of reutilization between the two groups (adjusted risk difference, 3%; 95% CI, –14.6 to 20.4). The adjusted mean hospital duration was significantly longer in the long-course group compared with the short-course group (adjusted mean difference, 6 days; 95% CI, 4.0 to 8.8).The authors of the study conclude, “Our data indicates that ≤7 days of parenteral antibiotic therapy may be safe in this population. Researchers in future prospective studies should seek to establish the bioavailability and optimal dosing of oral antibiotics in young infants and assess if there are particular subpopulations of infants with bacteremic UTI who may benefit from longer courses of parenteral antibiotic therapy.”Aug 20 Pediatrics study CARB-X awards funds for developing vaccine against resistant KlebsiellaCARB-X today said it is awarding Vaxxilon AG of Reinach, Switzerland, up to $1.4 million—and possibly more—to develop a multivalent vaccine to prevent infections caused by carbapenem-resistant Klebsiella pneumoniae, an invasive and deadly gram-negative bacterium.Arne von Bonin, PhD, chief scientific officer and head of immunology at Vaxxilon, said in a CARB-X news release, “CARB-X’s award will support the development of VXN-319, a semi-synthetic conjugate vaccine targeting multiple strains of Klebsiella pneumoniae, one of the top priority critical pathogens identified by the World Health Organization.”Vaxxilon said it expects the vaccine would protect against more than 80% of carbapenem-resistant strains of K pneumoniae. To create VXN-319, Vaxxilon scientists synthesized the carbohydrates that resemble the coating that surrounds each bacterial cell. They then combined the synthetic carbohydrates with other components to create a conjugate vaccine similar to those that have been approved to prevent infections from bacteria such as Streptococcus pneumoniae and Haemophilus influenzae type B.”Vaccines are vital tools in the fight against disease and drug-resistant bacteria, with the potential to prevent infections and reduce the spread of life-threatening bacteria,” said Kevin Outterson, JD, CARB-X executive director and professor of law at Boston University. “Vaxxilon’s vaccine, if approved for use in patients, could prevent deadly infections and save the lives of thousands of patients.”Vaxxilon could receive $3.1 million in additional funding if certain project milestones are met, according to CARB-X (the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator). Since its inception in 2016, CARB-X has announced awards for 46 projects in seven countries exceeding $134 million total.Aug 20 CARB-X news releaselast_img read more

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FTSE 100 holds on to last week’s gains

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Bhushan Steel to sell oxygen plant

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UK: Alicat Launches, Names Solway Challenger

first_img“Working closely with the utility over the past six months, we’re confident that we’ve delivered a high quality product that sets the standard for future operations and activity on the site.  As part of this contract, over the course of the next nine months, we’ll be manufacturing and delivering the final three workboats that together, help safeguard and protect the utilities wind energy operations in the future.”In the first six months of 2013, Alicat Workboats has manufactured and built one class-certified vessel and a further three non class-certified vessels, for the European market at its Great Yarmouth facility.This follows a £1.6m investment in the East coast boat yard earlier in the year that has seen the introduction of a 24-hour operational hoist designed for the fast lift out and turnaround of repairs, paint touch ups and defouling.In 2012, Alicat Workboats acquired South Boats IOW, a class-leading workboat manufacturer, with a dedicated facility on the Isle of Wight.Combined, the two complimentary businesses provide wind farm charter firms, developers and investors with a multi-site manufacturing, service and repair hub as well as a wide array of vessel selection and choice.The four-workboat order underlines the long-term commitment of Alicat Workboats to the offshore wind energy market.[mappress]Press Release, September 6, 2013 Alicat Workboats, a full service offshore wind farm workboat manufacturer and repair business, has successfully completed and launched the first of four offshore wind farm workboats for a major energy utility.The vessel has been  named ‘Solway Challenger’, following a naming ceremony that took place today at the dedicated seven-acre manufacturing and full-service workboat site that has direct access to the North Sea.The 19-metre workboat , that entered the water for the first time late last week, will now complete preliminary sea trials, with Alicat Workboats working closely with the energy utility throughout, before the vessel is deployed for long-term operations and maintenance work.The bespoke aluminum hulled catamaran offers a greater loading capacity across the fore deck, a completely redesigned saloon and island wheelhouse arrangement and was envisioned by Global Marine Design.  Powered by two MAN V12 engines and with jet propulsion supplied via twin Rolls Royce water jets, the vessel will be capable of 30 knots.“As the offshore wind energy market evolves, it’s imperative that utilities, developers, operators and investors have access to the right equipment at the right time, in order to undertake scheduled operations and maintenance programmes at notoriously hard to reach sites,” said Steve Thacker, General Manager Alicat Workboats.“For energy utilities in particular, this is especially important, if they are to ensure the uninterrupted production, transmission and supply of electricity to the UK grid.”last_img read more

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Who’s suing whom

first_imgSubscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe now for unlimited access To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Get your free guest access  SIGN UP TODAYlast_img read more

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International schools market: If you build it, they will buy it

first_imgStay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Subscribe now for unlimited accesslast_img read more

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‘Delay and expense’: High Court quashes disclosure orders

first_imgThe lord chief justice has taken the unusual step of reminding criminal defence practitioners that they are responsible for ensuring expert reports served on behalf of their clients are reliable.Quashing two disclosure orders in DPP v Walsall Magistrates’ Court and Lincoln Magistrates’ Court, published last week, Lord Burnett of Maldon and Mrs Justice May criticised the delay and expense caused by ‘unmeritorious’ applications for the disclosure of unused material relating to data from government-approved devices for standard prosecutions.The proceedings concerned judicial review applications brought by the director of public prosecutions for two separate drink-driving prosecutions. In both cases, after a defence statement was served, the district judge allowed a defence application for disclosure under section 8 of the Criminal Procedure and Investigations Act 1996, and ordered the prosecution to disclosure further material sought.  Lord Burnett of Maldon says defence representatives must ensure expert reports are reliable and admissibleIn one case, the prosecution argued that the material sought by the defence was not relevant. However, it disclosed an expired gas calibration certificate in relation to the breath-testing device.Lord Burnett and Mrs Justice May said the district judge’s first instinct, to refuse the disclosure application, was right: ‘The district judge was persuaded that the expiry of the gas calibration certificate overcame that difficulty. We respectfully disagree. He was right to adjourn the trial to enable the attendance of experts to speak to the relevance, if any, of that fact to the accuracy of the Intoxilyser readings; but that circumstance alone could not justify ordering the wider disclosure in the absence of any evidence establishing its relevance.’In the second case, the evidence supporting the dislcosure application was ‘inadequate’, and contained ‘generalised and unexplained assertions’.Lord Burnett and Mrs Justice May said ‘the disclosure issues raised before us are of broad application in very many other prosecutions being heard every day in magistrates’ courts throughout the country. Unmeritorious applications for disclosure of unused material relating to type-approved devices whose data form the basis of standard prosecutions cause delay and expense’.They were ‘troubled’ by the defence statements, or disclosure application, which they said relied on generalised, speculative complaints about a device approved under the Breath Devices Analysis Approval Order 2005.Defence representatives are responsible for ensuring experts understand the requirements of the Criminal Practice Rules and Directions ‘and that the expert reports which they serve on behalf of their clients are reliable and admissible’, their judgment concluded.last_img read more

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Hanoi metro Line 3 railway systems contract signed

first_imgVIETNAM: Hanoi Metropolitan Railway Management Board signed the railway systems contract for Hanoi metro Line 3 on January 17. The €265m contract has been awarded to a consortium of Alstom, Colas Rail and Thales. The consortium is led by Alstom, whose share of the contract is €190m. Alstom will supply 10 four-car Metropolis trainsets and Urbalis 400 CBTC signalling, as well as power supplies and depot equipment with Colas Rail. Thales will supply the telecoms and the control centre.Line 3 is the second metro line under construction in the capital, and is due to open in 2021. It will link the main railway station with Nhon, where there will be a maintenance depot. There would be eight stations on an 8·5 km elevated alignment and four on a 4 km underground section. It will initially have a capacity of 8 600 passengers/h per direction, which is due to rise in the first 10 years of operation.last_img read more

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Jamaica police launch manhunt for cop killer

first_imgJamaica police have launched a manhunt following the fatal shooting of one of their colleagues – Corporal Melvin Smith, late Friday. It’s reported that Smith, 38, who was assigned to the Community Safety and Security Branch of the Jamaica Constabulary Force (JCF), in the central parish of Manchester, was on duty when he was shot and killed.The police say that shortly after 8:00pm (local time), Smith was assisting a man who was robbed of his motorcycle.Shot several times“It became a running gun battle. The man gave chase after the thieves who fell from the motorcycle and subsequently got up and ran away. Another man opened fire, hitting Corporal Smith several times. He himself managed to return fire, but he collapsed and was taken to hospital where he died ….“ said head of the Manchester police, Superintendent Wayne Cameron.The robbery victim who was also shot, was admitted to hospital in stable condition.Police commissioner issues statementIn the aftermath of the incident, Police Commissioner George Quallo, said in a statement that everything will be done to find the killers. He said it was unfortunate that while performing his duty, Smith met “such cruelty and callousness.”Jamaica Police FederationAnd the Jamaica Police Federation, the body that represents the rank and file members of the JCF, says stronger action must be taken against those found guilty of killing members of the Force.According to the Chairman of the Federation, Sergeant Raymond Wilson, when members of the Force are killed, it shows a lack of regard for national security.Security minister appeals Meanwhile, National Security Minister Robert Montague is appealing to residents to provide information which can help in the capture of Smith’s killers. In a statement, Montague expressed regret at the killing, adding that the JCF has lost a valuable member, as Smith played an integral role in Police Youth Clubs in Manchester.For more on the volatile situation regarding Jamaica police, click the link: Members of the Jamaican police force have been warned to be on high alertlast_img read more

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CNW90 June 10, 2020

first_imgIn the meantime, the city of Miami Gardens has announced their rental assistance program, geared at providing financial aid for those who face evictions as a result of COVID-19. If selected, residents can receive a maximum of $4,500 per household. Applications for the program will end tomorrow, June 11. In light of the recent Minneapolis tragedy that has gained worldwide attention, law enforcement agencies across Broward County have announced that they will participate in the countywide Racial Equity and Implicit Bias Training Program for law enforcement officers. The program is one aspect of police reform that aims to combat racism and implicit bias among police officers. Broward Sheriff Gregory Tony announced that he was committing $1 million to fund the launch of this program, which is an increase of $500,000 that he initially committed to the initiative in 2019. Tony said that he hopes the program will bring about positive changes in the local police force, especially as it related to interactions with minority groups. To help stop the spread of COVID-19, The Florida Department of Health in Broward County reminds everyone to practice social distancing, wash your hands often with soap and water and cover your nose and mouth with a tissue or sleeve when coughing or sneezing. In Caribbean News, Guyana says that there will be a phased re-opening of the country’s airports to international flights beginning on July 1. For the entire month of July, there will be limited incoming flights for citizens, permanent residents, international workers and diplomats. Now for the news in the detail Coming up in the newscast, Broward Sheriff dedicated $1 million to racial equity police program, family of slain Jamaican-native, Maurice Gordon, calls for justice and Miami Gardens announces rent assistance program. With a look at some of the top stories making the news today, June 10 across your Caribbean-American community in South Florida. In the meantime, Jamaicans locally and abroad are calling for justice for the death of, Maurice Gordon, a Jamaican-native who was shot dead during a routine traffic stop by a state trooper in New Jersey. The incident occurred on May 23 along the Garden State Parkway in Bass River, New Jersey, just two days before the death of George Floyd. According to reports, 28-year-old Gordon was pulled over by the trooper for speeding. When the trooper asked Gordon to drive his car to a different spot on the highway, the car would not start. The trooper then called for a tow truck. After being held in the trooper’s vehicle for 30 minutes without a ticket or any indication that he was under arrest, Gordon attempted to flee the vehicle and was shot and killed by the trooper. The family of Gordon said they want a nationwide spotlight on his death, in the hopes that justice will be served. For more information on these and other stories, visit CNWNETWORK.com. Remember to pick up this week’s copy of our Caribbean National Weekly at your nearest Caribbean – American outlet. Today’s newscast is brought to you by the Florida Department of Health; You’ve been watching CNW90.last_img read more

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